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        The Total Synthesis of Depsilairdin

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        SandipPardeshiPhDThesis.pdf (2.105Mb)
        Date
        2009
        Author
        Pardeshi, Sandip Govindsing
        Type
        Thesis
        Degree Level
        Doctoral
        Abstract
        Dessertation describes of the first reported syntheses of the natural products lairdinol A and depsilairdin. The key steps in the synthesis of depsilairdin were N-terminal extension (C←N) of the protected proline fragment, hydrolysis of the tetrapeptide fragment with free secondary alcohol in the proline moiety and esterification of the HOBt ester of tetrapeptide fragment with the bromomagnesium alkoxide of lairdinol A.
        Degree
        Doctor of Philosophy (Ph.D.)
        Department
        Chemistry
        Program
        Chemistry
        Supervisor
        Ward, Dale E
        Committee
        Urquhart, Stephen; John, Balsevich; David, Palmer; Michel, Gravel
        Copyright Date
        2009
        URI
        http://hdl.handle.net/10388/etd-12152009-175940
        Subject
        blackleg disease
        host-selective
        phytotoxins
        lairdinol A
        depsilairdin
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