REALIZATION OF A CANINE POSITIONING DEVICE FOR IN SITU PROSTATE PHASE CONTRAST – COMPUTED TOMOGRAPHY IMAGING
Keith, Jay D 1992-
Background: Worldwide, prostate cancer (PCa) is the most commonly diagnosed non-skin cancer in men. The current diagnostic standard of PCa requires invasive procedures such as needle biopsies. Non-invasive medical imaging techniques, such as Computed Tomography (CT), are only used as an adjunct for staging PCa. The development of a novel non-invasive imaging technique for PCa could revolutionize diagnostic standards and improve patient prognosis. The similarity between canine and human prostates, as well as similar PCa pathophysiology, makes the dog an ideal model for human PCa research. Initial investigations with Phase Contrast – CT (PC-CT) has shown potential for detecting morphological abnormalities in ex vivo canine prostates and therefore warrants further testing as a potential PCa diagnostic imaging technique. This research addresses the design, development and implementation of a canine positioning device used for in situ prostate PC-CT imaging on the Biomedical Imaging and Therapy –Insertion Device Beamline at the Canadian Light Source. This device is currently being used to collect micron-level resolution PC-CT reconstructions of canine cadaver prostates. This thesis lays the ground work for canine imaging on the BMIT – ID beamline at the CLS. The design and implementation of the device are described, along with the issues discovered and addressed.
DegreeMaster of Science (M.Sc.)
SupervisorPettitt, Murray; Snead, Elisabeth
CommitteePettitt, Murray; Snead, Elisabeth; Singh, Jaswant; Chapman, Dean L; Gray, Jack
Copyright DateMay 2017
Phase-Contrast Computed Tomography, Prostate Cancer, Canine Prostate, In Situ Imaging, Synchrotron Imaging, Biomedical Engineering